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If you attempt to use the 64 version of REGSVR32.EXE on a .net dll, the dll will be jit compiled and ran as a 64 bit process, and similarly if you use 32 bit version of REGSVR32 you get a 32 bit process. The exception to this is of course, if your dll targets a specific platform. So if your .net dll relies on an unmanaged dll, your .Net dll either needs to target the same platform as your unmanaged dll or you need to ensure you launch the correct version of REGSVR32.EXE.